Группа структурных исследований макромолекулярных комплексов

Азат Габдрахманович Габдулхаков

Кандидат физико-математических наук c 2005 г.
 

Сотрудники

А. А. Атамас
И. А. Коляденко
Г. К. Селиханов
Б. Ф. Фатхуллин

Основные научные достижения

В разработке...

Перспективы исследований

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PubMed
The role of positive charged residue in the proton-transfer mechanism of two-domain laccase from Streptomyces griseoflavus Ac-993.

Azat Gabdulkhakov, Ilya Kolyadenko, Paulo Oliveira, Paula Tamagnini, Alisa Mikhaylina, Svetlana Tishchenko.

J Biomol Struct Dyn. 2021; 1-8. doi: 10.1080/07391102.2021.1911852. Online ahead of print.
2021
PubMed
PubMed
Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach.

Khusainov I, Fatkhullin B, Pellegrino S, Bikmullin A, Liu WT, Gabdulkhakov A, Shebel AA, Golubev A, Zeyer D, Trachtmann N, Sprenger GA, Validov S, Usachev K, Yusupova G, Yusupov M.

Nat Commun. 2020 Apr 3;11(1):1656. doi: 10.1038/s41467-020-15517-0. PMID: 32245971; PMCID: PMC7125091.
2020
PubMed
PubMed
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.

Golubev A, Fatkhullin B, Khusainov I, Jenner L, Gabdulkhakov A, Validov S, Yusupova G, Yusupov M, Usachev K.

FEBS Lett. 2020 Nov;594(21):3551-3567. doi: 10.1002/1873-3468.13915. Epub 2020 Sep 10. PMID: 32852796
2020
PubMed
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Structure of the ribosomal P stalk base in archaean Methanococcus jannaschii.

Gabdulkhakov A, Mitroshin I, Garber M.

J Struct Biol. 2020 Sep 1;211(3):107559. doi: 10.1016/j.jsb.2020.107559. Epub 2020 Jul 10. PMID: 32653645
2020
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PubMed
In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors.

Nass, K; Redecke, L; Perbandt, M; Yefanov, O; Klinge, M; Koopmann, R; Stellato, F; Gabdulkhakov, A; Schonherr, R; Rehders, D; Lahey-Rudolph, JM; Aquila, A; Barty, A; Basu, S; Doak, RB; Duden, R; Frank, M; Fromme, R; Kassemeyer, S; Katona, G; Kirian, R; Liu, H; Majoul, I; Martin-Garcia, JM; Messerschmidt, M; Shoeman, RL; Weierstall, U; Westenhoff, S; White, TA; Williams, GJ; Yoon, CH; Zatsepin, N; Fromme, P; Duszenko, M; Chapman, HN; Betzel, C

Nat Commun. 2020 Jan 30;11(1):620. doi: 10.1038/s41467-020-14484-w.
2020
PubMed
PubMed
NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus.

Golubev, A; Fatkhullin, B; Gabdulkhakov, A; Bikmullin, A; Nurullina, L; Garaeva, N; Islamov, D; Klochkova, E; Klochkov, V; Aganov, A; Khusainov, I; Validov, S; Yusupova, G; Yusupov, M; Usachev, K.

Eur Biophys J. 2020 May;49(3-4):223-230. doi: 10.1007/s00249-020-01428-x. Epub 2020 Mar 9.
2020
PubMed
PubMed
The key role of E418 carboxyl group in the formation of Nt.BspD6I nickase active site: Structural and functional properties of Nt.BspD6I E418A mutant.

Artyukh, RI; Kachalova, GS; Yunusova, AK; Fatkhullin, BF; Atanasov, BP; Perevyazova, TA; Popov, AN; Gabdulkhakov, AG; Zheleznaya, LA

JOURNAL OF STRUCTURAL BIOLOGY 2020 Jun 1;210(3):107508. doi: 10.1016/j.jsb.2020.107508. Epub 2020 Apr 13.
2020
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PubMed
Dimerization of long hibernation promoting factor from Staphylococcus aureus: Structural analysis and biochemical characterization.

Usachev K.S., Fatkhullin B.F., Klochkova E.A., Miftakhov A.K., Golubev A.A., Bikmullin A.G., Nurullina L.I., Garaeva N.S., Islamov D.R., Gabdulkhakov A.G., Lekontseva N.V., Tishchenko S.V., Balobanov V.A., Khusainov I.S., Yusupov M.M., Validov S.Z.

J. Struct. Biol. 2019, 25:107408. doi: 10.1016/j.jsb.2019.107408.
2020
PubMed
Идентификация каналов т2/t3 центра двухдоменных лакказ.

С.В. Тищенко, И.А. Коляденко, А.Г. Габдулхаков

Acta Naturae. 2019; спецвыпуск том 2: 86.
2019
abstract
Crystallization in lipid mesophases affects pigment composition of photosynthetic reaction center

Selikhanov, G (Selikhanov, G.); Fufina, T (Fufina, T.); Vasilieva, L (Vasilieva, L.); Gabdulkhakov, A

FEBS OPEN BIO P-27-027, 9: 255-256 WOS:000486972403185
2019
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PubMed
Controlling Photosynthetic Excitons by Selective Pigment Photooxidation

Leiger, K (Leiger, Kristjan); Linnanto, JM (Linnanto, Juha Matti); Ratsep, M (Ratsep, Margus); Timpmann, K (Timpmann, Kou); Ashikhmin, AA (Ashikhmin, Aleksandr A.); Moskalenko, AA (Moskalenko, Andrey A.); Fufina, TY (Fufina, Tatiana Y.); Gabdulkhakov, AG (Gabdulkhakov, Azat G.); Freiberg, A (Freiberg, Arvi)

JOURNAL OF PHYSICAL CHEMISTRY B Том: 123 Выпуск: 1 Стр.: 29-38 DOI: 10.1021/acs.jpcb.8b08083 WOS:000455560800009 PubMed: 30543422
2019
PubMed
abstract
Serine bacteriolytic protease L1 of Lysobacter sp. XL1 complexed with protease inhibitor AEBSF: features of interaction

Kudryakova, IV (Kudryakova, Irina V.); Gabdulkhakov, AG (Gabdulkhakov, Azat G.); Tishchenko, SV (Tishchenko, Svetlana V.); Afoshin, AS (Afoshin, Alexey S.); Vasilyeva, NV (Vasilyeva, Natalia V.)

PROCESS BIOCHEMISTRY Том: 80 Стр.: 89-94 DOI: 10.1016/j.procbio.2019.02.013 WOS:000466616800012
2019
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abstract
Fab Fragment of VHH-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A

Kostareva, O (Kostareva, Olga); Kolyadenko, I (Kolyadenko, Ilya); Ulitin, A (Ulitin, Andrey); Ekimova, V (Ekimova, Victoria); Evdokimov, S (Evdokimov, Stanislav); Garber, M (Garber, Maria); Tishchenko, S (Tishchenko, Svetlana); Gabdulkhakov, A (Gabdulkhakov, Azat)

CRYSTALS Том: 9 Выпуск: 3 Номер статьи: 177 DOI: 10.3390/cryst9030177 WOS:000464478100002
2019
abstract
PubMed
Interleukin-17: Functional and Structural Features, Application as a Therapeutic Target

Kostareva, OS (Kostareva, O. S.); Gabdulkhakov, AG (Gabdulkhakov, A. G.); Kolyadenko, IA (Kolyadenko, I. A.); Garber, MB (Garber, M. B.); Tishchenko, SV (Tishchenko, S. V.)

BIOCHEMISTRY-MOSCOW Том: 84 Стр.: 193-205 DOI: 10.1134/S0006297919140116 WOS:000468501300011 PubMed: 31213202
2019
PubMed
PubMed
Investigations of Accessibility of T2/T3 Copper Center of Two-Domain Laccase from Streptomyces griseoflavus Ac-993

Gabdulkhakov, A (Gabdulkhakov, Azat); Kolyadenko, I (Kolyadenko, Ilya); Kostareva, O (Kostareva, Olga); Mikhaylina, A (Mikhaylina, Alisa); Oliveira, P (Oliveira, Paulo); Tamagnini, P (Tamagnini, Paula); Lisov, A (Lisov, Alexander); Tishchenko, S

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Том: 20 Выпуск: 13 Номер статьи: 3184 DOI: 10.3390/ijms20133184 WOS:000477041100072 PubMed: 31261802
2019
PubMed
PubMed
Properties of Rhodobacter sphaeroides Reaction Centers with the Ile -> Tyr Substitution at Positions L177 and M206

Fufina, TY (Fufina, T. Yu); Selikhanov, K (Selikhanov, K.); Proskuryakov, II (Proskuryakov, I. I.); Shuvalov, VA (Shuvalov, V. A.); Vasilieva, LG (Vasilieva, L. G.)

BIOCHEMISTRY-MOSCOW Том: 84 Выпуск: 5 Стр.: 570-574 DOI: 10.1134/S0006297919050110 WOS:000468032800011 PubMed: 31234771
2019
PubMed
abstract
Crystal structure of the complex ribosomal silencing factor S and ribosomal protein L14 from Staphylococcus aureus

Fatkhullin, B (Fatkhullin, B.); Gabdulkhakov, A (Gabdulkhakov, A.); Validov, S (Validov, S.); Khusainov, I (Khusainov, I.); Bikmullin, A (Bikmullin, A.); Usachev, K (Usachev, K.); Yusupov, M

FEBS OPEN BIO Аннотация к встрече: P-34-010 Том: 9 Стр.: 316-316 WOS:000486972405001
2019
abstract